Pawhuskin A
Pawhuskin A is a naturally occurring prenylated stilbene isolated from Dalea purpurea which acts as a competitive silent antagonist of the κ-, μ-, and δ-opioid receptors. The compound was named after Pawhuska, Oklahoma, a place near where the samples of Dalea purpurea that led to its discovery were taken from. Other isolates of the plant with affinity for opioid receptors include Pawhuskin B and Pawhuskin C, though these compounds produce comparatively weak opioid receptor displacement relative to Pawhuskin A. Dalea purpurea was used in Native [American ethnobotany|traditional Native American medicine] to treat various ailments, and pawhuskin A and related isolates may be some of the constituents of the plant which underlay this use.