Paul O'Brien
Paul O'Brien may refer to:
- Paul O'Brien (scholar), Irish language scholar and Catholic priest
- Paul O'Brien (Australian footballer, born 1948), VFL footballer for Fitzroy
- Paul O'Brien (Australian footballer, born 1950), VFL footballer for Carlton
- Paul O'Brien (chemist), professor of chemistry
- Paul O'Brien (Australian footballer, born 1961), VFL footballer for Essendon and Melbourne
- Paul O'Brien (Scottish footballer), Scottish footballer
- Paul O'Brien (equestrian), New Zealand equestrian
- Paul O'Brien (actor), Australian actor
- Paul O'Brien (rugby league), Australian rugby league footballer of the 1970s