Paul Babitzke

Paul Babitzke is a professor of biochemistry and molecular biology and director of the Center for RNA Molecular Biology at Pennsylvania State University.

Education

Paul Babitzke obtained his B.A. in biomedical science from St. Cloud State University in Minnesota in 1994. He earned his Ph.D. in genetics from the University of Georgia in 1991.

Career

Before he started at Penn State University in 1994, Babitzke worked as a postdoctoral scientist at Stanford University's department of biological sciences for 3 years. Currently, he is professor of biochemistry and molecular biology at Penn State.
He became an assistant professor of biochemistry and molecular biology in 1994 and associate professor in 2000. In 2006, Babitzke was promoted to full professor.
Since 2009, he has been serving as director of the Center for RNA Molecular Biology in the Penn State Huck Institutes of the Life Sciences. His research focuses on the regulation of gene expression mediated by RNA polymerase pausing, transcription termination, RNA structure, and RNA-binding proteins.
In 2016, he was elected as Fellow of the American Association for the Advancement of Science.
In 2017, he was elected as Fellow of the American Academy of Microbiology.

Honors and awards

Chair, Division H, American Society for Microbiology
Chair, NIGMS Microbial Physiology and Genetics-subcommittee 2
Daniel R. Tershak Teaching Award
Divisional Group IV Representative, American Society for Microbiology
Charles E. Kaufman New Initiative Research Award
Fellow, American Association for the Advancement of Science
Fellow, American Academy of Microbiology
St. Cloud State University Biological Sciences Distinguished Alumni Award

Selected publications

Baker, C.S., Morozov, I., Suzuki, K., Romeo, T., and Babitzke, P. CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli. Mol. Microbiol. 44:1599-1610.
Yakhnin, A.V., and Babitzke, P. NusA-stimulated RNA polymerase pausing and termination participates in the Bacillus subtilis trp operon attenuation mechanism in vitro. Proc. Natl. Acad. Sci. USA. 99:11067-11072.
Yakhnin, A.V., Yakhnin, H., and Babitzke, P. RNA polymerase pausing participates in the Bacillus subtilis trpE translation control mechanism by providing additional time for TRAP to bind to the nascent trp leader transcript. Mol. Cell 24:547-557.
Yakhnin, A.V., Yakhnin, H., and Babitzke, P. Function of the Bacillus subtilis transcription elongation factor NusG in hairpin-dependent RNA polymerase pausing in the trp leader. Proc. Natl. Acad. Sci. USA 105:16131-16136.
Yakhnin, H., Yakhnin, A.V., Baker, C.S., Sineva, E., Berezin, I., Romeo, T., and Babitzke, P. Complex regulation of the global regulatory gene csrA: CsrA-mediated translational repression, transcription from five promoters by Es⁷⁰ and Es^S, and indirect transcriptional activation by CsrA. Mol. Microbiol. 81:689-704.
Yakhnin, A.V., Baker, C.S., Vakulskas, C.A., Yakhnin, H., Berezin, I., Romeo, T., and Babitzke, P. CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage. Mol. Microbiol. 87:851-866.
Mondal, S., Yakhnin, A.V., Sebastian, A., Albert, I., and Babitzke, P. NusA-dependent transcription termination prevents misregulation of global gene expression. Nat. Microbiol. 1:15007.
Potts, A.H., Vakulskas, C.A., Pannuri, A., Yakhnin, H., Babitzke, P., and Romeo, T. Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics. Nat. Commun. 8:1596.
Yakhnin, A.V., FitzGerald, P.C., McIntosh, C., Yakhnin, H., Kireeva, M., Turek-Herman, J., Mandell, Z.F., Kashlev, M., and Babitzke, P. NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome. Proc. Natl. Acad. Sci. USA 117:21628-21636.
Mandell, Z.F., Oshiro, R.T., Yakhnin, A.V., Kashlev, M., Kearns, D.B., and Babitzke, P. NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA. eLife 10:e61880.