Bonomini was born in Bergamo to an artist father Paolo Maria, who encouraged his son's artistic study. Bonomini's early works were done in a rococo style that later developed into neoclassical. He worked in many fields. He left as a decorator of civil and sacred, but reached the popularity for his portraits, and especially for his caricatures. From 1824 to 1827 he had the painter Giuseppe Macinata as a pupil.