The structure was built during the 18th century and substantially renovated during the next one. The palace was the residence of Andrea Memmo, an elected prosecutor in 1775, who is known for his friendship with Giacomo Casanova. The palazzo passed to cav. Luigi Mandelli in 1886. After several structures neighboring the palace on the right had been demolished, the right wing was rebuilt to add a garden. The palazzo has housed several public offices.