PSKH1

Protein Serine/threonine-protein kinase H1 is a Ser/Thr protein kinase that is encoded by the PSKH1 gene in humans and is associated with organelle membranes. PSKH1 resides within, and transits between, organelles in the human secretory pathway notably the Endoplasmic Reticulum.

Interactions

PSKH1 is a regulated protein kinase with a defined substrate specificity, which has been shown to interact with proteins of the Cab45, reticulocalbin, Erc55, and calumenin family of calcium-binding proteins and calmodulin. It is also activated by UNC119B, an acyl chain binding protein. PSKH1 is closely related to the catalytically-inactive pseudokinase PSKH2, which is also membrane-localised within the secretory pathway.