List of Pennsylvania Railroad lines west of Pittsburgh
The following railroad lines were owned or operated by the Pennsylvania Railroad west of Pittsburgh and Erie.
Pittsburgh to Chicago
- Main Line (Pittsburgh to Chicago)
- *Economy Branch
- *Block House Run Branch
- *North Rochester Branch
- *Marginal Branch
- *Oil Street Branch
- *South Canton Branch
- *Buck Hill Branch
- *South Massillon Branch
- *Massillon and Cleveland Branch
- *Walhonding Branch
- *Rocky Fork Branch
- *Toledo Branch
- **Water Street Branch
- **River Branch
- **Oakman Branch
- **West Belt Branch
- *Grand Rapids Branch
- **Muskegon Branch
- **Missaukee Branch
- **Traverse City Branch
- **Harbor Springs Branch
- *State Line and Indiana City Railway
- **Wolf Lake Branch
- **Hammond Branch
- *South Chicago and Southern Railroad
- *Calumet River Line
- *Cummings Branch
- *Calumet Western Railway
- Cleveland Line
- *Beaver Valley Railroad Branch
- *River Branch
- **Wheeling Terminal Branch
- **POV&C Railroad Branch
- ***Wegee Branch
- *Salineville Railroad
- *Canton-Bayard Branch
- *Tuscarawas Branch
- **Brush Run Branch
- **Marietta Branch
- **Strasburg Branch
- *Akron Branch
- **Dresden Branch
- **Howard Branch
- *Maple Heights Industrial Branch
- *Kingsbury Branch
- *Silver Plate Branch
- New Brighton to Ashtabula Harbor
- *Kenwood Branch
- *Beaver Valley Branch
- *Mahoningtown Branch
- **Erie and Pittsburgh Branch
- ***Sharpsville Branch
- **New Castle Branch
- ***Wilmington Branch
- ***Wolf Creek Branch
- *Bessemer Branch
- *Canfield Branch
- *Alliance Branch
- Sandusky Branch
Pittsburgh to St. Louis
- Main Line (Pittsburgh, PA to St. Louis, MO)
- *Ohio Connecting Railway
- **Duffs Branch
- **Sheridan Branch
- *Chartiers Branch
- **Bridgeville and McDonald Branch
- **Westland Branch
- ***Palanka Branch
- *Burgetts Branch
- **Hickory Branch
- **Langeloth Branch
- *New Cumberland Branch
- *Wheeling Branch
- *Cadiz Branch
- **Georgetown Branch
- *Zanesville Branch
- **Mill Run Branch
- *Springfield Branch
- *C&X Branch
- **Middletown Branch
- **Undercliff Branch
- **Richmond Branch
- ***Fort Wayne Branch
- *Lebanon Branch
- **Montgomery Branch
- **Hempstead Branch
- *Louisville Branch
- **Madison Branch
- **Shelbyville Branch
- **New Albany Branch
- **Arbegust Street Branch
- *Vincennes Branch
- **Starch Works Branch
- **Greene County Coal Branch
- **Columbia Branch
- **Knox County Coal Branch
- *Vandalia Railroad
- **St. Louis, Vandalia and Terre Haute Railroad
- **Terre Haute and Indianapolis Rail Road
- **Terre Haute and Logansport Branch
- **Logansport and Toledo Branch
- *I&F Branch
- *Centerpoint Branch
- *Hadleytown Branch
- *Saline City Branch
- *Willow Creek Branch
- *Furnace Branch
- *Glen Ayr Branch
- *Crawfordsville Branch
- *Macksville North Branch
- *Macksville South Branch
- *Peoria Branch
- *Highland Mill Branch
- *Troy Branch
- *Stock Yards Branch