PRB
- Brazilian Republican Party
- PRB (vessel)
- PRB Sailing Team
- Parti Rakyat Brunei
- Paso Robles Municipal Airport
- People's Republic of Benin
- People's Republic of Bulgaria
- People’s Republic of Bangladesh
- Periodic Review Board
- Permeable reactive barrier
- Physical Review B
- Population Reference Bureau
- Poudreries Réunies de Belgique
- Powder River Basin
- Pre-Raphaelite Brotherhood
- Progesterone receptor B
- Retinoblastoma protein
- Transnistrian rubla