PORCN


PORCN is a human gene.
The protein is homologous to other membrane-bound O-acyltransferases.

Function

The protein encoded by this gene is an endoplasmic reticulum transmembrane protein involved in processing of wingless proteins such as WNT7A. It performs O-Palmitoleoylation of these proteins.

Clinical significance

Mutations in this gene are associated with focal dermal hypoplasia.
Mutations in PORCN are associated to Goltz-Gorlin syndrome.

Ligands

Inhibitors

IWP
RXC004