PLS
- IBM PL/S
- IPS panel
- Oklahoma Panhandle
- PL (disambiguation)
- PLS (complexity)
- PLS (file format)
- PLS on Post
- PLSS (disambiguation)
- Palletized load system
- Palomar–Leiden survey
- Papillon–Lefèvre syndrome
- Partial least squares regression
- Pilbara Minerals
- Pioneer Library System
- Plastin
- Please (disambiguation)
- Pleasington railway station
- Plis (disambiguation)
- Poculi Ludique Societas
- Polish Lowland Sheepdog
- Polish Volleyball League
- Pregnant leach solution
- Premier League Soccer (India)
- Primary lateral sclerosis
- Profit and loss sharing
- Prometheus Light and Sound
- Pronunciation Lexicon Specification
- Proteus-like syndrome
- Providenciales International Airport
- Texting shorthand
- Voyager program