PLEKHM1
Pleckstrin homology domain-containing family M member 1 also known as PLEKHM1 is a protein that in humans is encoded by the PLEKHM1 gene.
Function
PLEKHM1 may have critical function in vesicular transport in osteoclasts.PLEKHM1 contains a C-terminal Rubicon [homology domain|Rubicon Homology (RH) domain], which mediates interaction with small GTPase Rab7. This domain is shared with family RH domain containing family members Rubicon and Pacer, which are autophagy regulators.