PKC- Reduced DUSP4 Expression Causing NOX4 and Progressive Diabetic Nephropathy
PKC- Reduced DUSP4 Expression Causing NOX4 and Progressive Diabetic Nephropathy is a scholarly work, published in 2018 in ''Canadian Journal of Diabetes''. The main subjects of the publication include medicine, NOX4, diabetic nephropathy, kidney, NADPH oxidase complex, downregulation and upregulation, protein tyrosine phosphatase, ciliopathy, kinase, diabetes, Endoplasmic Reticulum Stress in Beta Cells, endocrinology, protein kinase C, cell biology, internal medicine, podocyte, and kidney disease. The authors have observed that cultured podocytes exposed to high glucose (HG; 25 mM) concentrations and glomeruli of diabetic (Ins2+/C96Y) mice exhibited a significant reduction of DUSP4, which complied with glomerularsclerosis, podocyte effacement and podocyte cell death.