PIAS4

E3 SUMO-protein ligase PIAS4 is one of several protein [inhibitor of activated STAT] proteins. It is also known as a protein inhibitor of activated STAT protein gamma, and is an enzyme that in humans is encoded by the PIAS4 gene.

Interactions

PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6, Mothers against decapentaplegic homolog 7 and Lymphoid enhancer-binding factor 1. PIAS4 has been shown to be responsible for the SUMOylation of inhibited Werner syndrome helicase trapped on DNA in microsatellite unstable cancer cells.