Oxyphencyclimine

Oxyphencyclimine is a muscarinic [receptor antagonist], given orally to treat peptic [ulcer disease] and gastrointestinal spasms. It has antispasmodic and antimotility properties.

Synthesis

The reaction of chloroacetonitrile with methanol and hydrogen chloride leads to the corresponding iminoether. Condensation of 2 with 3-methylaminopropylamine gives gives the corresponding tetrahydropyrimidine. Displacement of the halogen with the sodium salt 5 affords oxyphencyclimine.