William Osborne
William Osborne or Osborn may refer to:
- Bill Osborne, New Zealand rugby player
- Qwominer William Osborne, British Virgin Islands politician
- Will Osborne (rugby), Welsh rugby player
- Will Osborne (singer), Canadian singer
- William Osborne (umpire), National League umpire in 1876
- William Osborne (writer), English writer
- William Alexander Osborne, Australian professor of Physiology
- William G. Osborne in District Attorney's Office v. Osborne, a U.S. Supreme Court case
- William H. Osborne, president and CEO of Federal Signal Corporation
- Sir William Osborne, 8th Baronet, Irish baronet and politician
- William Osborn (Medal of Honor), American soldier
- William A. Osborn, American bank executive
- William Church Osborn, New York State Democratic Committee Chairman
- William H. Osborn, American railroad tycoon
- William Evelyn Osborn, British artist