Omar M. Yaghi


Omar Mwannes Yaghi is a chemist best known for developing metal–organic frameworks and pioneering reticular chemistry. He was awarded the 2025 Nobel Prize in Chemistry, shared with Richard Robson and Susumu Kitagawa, for this work.
Yaghi is a University Professor and James and Neeltje Tretter Endowed Chair in Chemistry at the University of California, Berkeley. He is also an affiliate scientist at Lawrence Berkeley National Laboratory, founding director of the Berkeley Global Science Institute, and a member of the U.S. National Academy of Sciences and the German National Academy of Sciences Leopoldina. In January 2025, he became the seventh president of the World Cultural Council, an international organization promoting cultural and scientific advancement.
WWW yaghi.berkeley.edu/bio.ht...

Early life and education

Omar Mwannes Yaghi was born in Amman, Jordan, on February 9, 1965, to a Palestinian refugee family that had fled from Masmiya during the 1948 Arab-Israeli War. He grew up in a crowded household with many children, all living in a single room that also housed the family's livestock. The family had limited access to clean water.
At the age of 15, encouraged by his father, he moved to the United States. Although he knew little English, he began classes at Hudson Valley Community College. He graduated in 1983 with an Associate of Science in Mathematics and Science. He then transferred to the State University of New York at Albany, where he completed his Chemistry Bachelor of Science degree in 1985. He pursued his graduate studies at the University of Illinois at Urbana–Champaign, earning his PhD in 1990 under the guidance of Walter G. Klemperer. He then served as a National Science Foundation postdoctoral fellow at Harvard University under Richard H. Holm.
In 2021, Yaghi was granted Saudi citizenship by royal decree.

Academic career

Yaghi began his academic career as an assistant professor at Arizona State University. He then held the Robert W. Parry Professorship of Chemistry at the University of Michigan, followed by the Christopher S. Foote Professorship of Chemistry and the Irving and Jean Stone Chair in Physical Sciences at the University of California, Los Angeles.
In 2012, he moved to the University of California, Berkeley, where he is the James and Neeltje Tretter Professor of Chemistry. From 2012 to 2013, he served as the director of the Molecular Foundry at the Lawrence Berkeley National Laboratory. He is the Founding Director of the Berkeley Global Science Institute and a co-director of the Kavli Energy NanoSciences Institute, a partnership between UC Berkeley and the Lawrence Berkeley National Laboratory. He also co-directs the California Research Alliance by BASF and the Bakar Institute of Digital Materials for the Planet.
In May 2025, the University of California Board of Regents promoted Yaghi to the rank of University Professor, the system's highest honor reserved for scholars of the highest international distinction.

Research

Reticular chemistry

Yaghi is the pioneer of reticular chemistry, a field dedicated to assembling molecular building blocks into open, crystalline frameworks using strong bonds.
According to the International Balzan Prize Foundation, Yaghi first proposed using molecular building blocks and strong bonds to form crystalline materials in the early 1990s. At the time, the scientific community considered this idea chemically unfeasible, as such syntheses typically resulted in non-crystalline, amorphous solids. However, in 1995, Yaghi successfully crystallized metal-organic structures in which metal ions are connected by charged organic linkers, such as carboxylates, via strong bonds. This breakthrough led to the development of a new class of materials known as metal–organic frameworks, marking the birth of reticular chemistry.

Metal-organic frameworks

Yaghi's most recognized work is in the design, synthesis, application, and popularization of metal-organic frameworks. According to IUPAC, MOFs are a subclass of coordination polymers, a category first reported in 1959. Earlier work included E. A. Tomic's 1965 study on the thermal stability of various coordination polymers and the work of Hoskins and Richard Robson in 1989 on a 3D coordination polymer structure. However, these early coordination polymers were typically frail, disordered structures with poorly defined properties.
In the 1990s, Yaghi made three key breakthroughs that transformed fragile coordination polymers into the architecturally robust, permanently porous MOFs in use today:
  1. The crystallization of metal-organic structures using strong bonds between metal ions and charged organic linkers like carboxylates.
  2. The introduction of metal-carboxylate clusters as secondary building units, which enabled robust frameworks with permanent porosity, later confirmed by gas adsorption isotherms.
  3. The realization of ultra-high porosity with MOF-5.
The strong bonds in MOFs are fundamental to their structural robustness, ultra-high porosity, and longevity in industrial applications.

Covalent organic frameworks

In 2005, Omar M. Yaghi published the seminal paper on covalent organic frameworks, reporting the first series of 2D COFs. This work demonstrated the design and synthesis of COFs via condensation reactions of and 2,3,6,7,10,11-hexahydroxytriphenylene. Powder X-ray diffraction of the highly crystalline products—with empirical formulas and —revealed 2D expanded porous graphitic layers with either staggered or eclipsed structures. These architectures are held together by strong covalent bonds between boron, carbon, and oxygen atoms, creating rigid porous structures with pore sizes ranging from 7 to 27 ångströms. COF-1 and COF-5 exhibit high thermal stability, permanent porosity, and high surface areas of 711 and 1590 square meters per gram, respectively.
The synthesis of 3D COFs had been hindered by longstanding practical and conceptual challenges until Yaghi's group first achieved it in 2007.
Yaghi also pioneered the design and production of zeolitic imidazolate frameworks. MOFs, COFs, and ZIFs are renowned for their extreme properties, such as very high surface areas and very low crystalline densities.

Molecular weaving

Yaghi pioneered the field of molecular weaving, achieving the first synthesis of a material woven at the atomic and molecular levels.
He has led efforts to apply reticular materials in clean energy technologies, including hydrogen and methane storage, carbon dioxide capture, and harvesting water from desert air.
According to a Thomson Reuters analysis, Yaghi was the world's second-most-cited chemist between 2000 and 2010.

Entrepreneurship

In 2020, Yaghi founded Atoco, a California-based startup focused on commercializing his advancements in MOF and COF technologies for carbon capture and atmospheric water harvesting.
In 2021, he co-founded a second startup, H2MOF, which applies his discoveries in reticular chemistry to address challenges in hydrogen storage.

Honors and awards

Yaghi has received numerous international awards and medals, including the Nobel Prize in Chemistry, the Albert Einstein World Award of Science, the Wolf Prize in Chemistry, the Gregori Aminoff Prize, the VinFuture Prize, and the Science for the Future Ernest Solvay Prize. His key honors include: