OSD
- International Electrotechnical Commission
- Object storage device
- Ocean Science Discussions
- Office of the Secretary of Defense
- Officer on Special Duty
- Oklahoma School for the Deaf
- Olympia School District
- On-screen display
- One Shot Deal
- Open Source Definition
- OpenSearch (specification)
- Optimal shape design
- Oral sedation dentistry
- Oregon School for the Deaf
- Orthotropic deck
- Osgood–Schlatter disease
- Overseas Surveys Directorate
- Oxnard Elementary School District
- System Center Configuration Manager
- Åre Östersund Airport