ORG-37684

ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT₂ receptor family, including of the serotonin 5-HT_2C, 5-HT_2B, and 5-HT_2A receptors, in that order of potency. It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans. ORG-37684 produces the head-twitch response, a behavioral proxy of psychedelic effects, and hence may be hallucinogenic in humans. The drug was under development for the treatment of major depressive disorder in the 1990s and early 2000s, and reached the preclinical research stage, but development was discontinued and it was never marketed.