OPM
- Affiliate marketing
- Free Papua Movement
- Harvard Business School
- O.P.M. Leasing Services
- OPM (album)
- OPM (band)
- Oak processionary
- Object Process Methodology
- Office of Production Management
- Official U.S. PlayStation Magazine
- Oklahoma Office of Personnel Management
- Online program manager
- Opportunistic Mesh
- Optical performance monitoring
- Organizational Project Management
- Orientations of Proteins in Membranes database
- Original Pilipino Music
- Other people's money (disambiguation)
- PlayStation Official Magazine – UK
- Political Military Organization
- United States Office of Personnel Management
- Yamaha YM2151