ODS
- Civic Democratic Party (Czech Republic)
- Civic Democratic Party (Slovakia)
- Files-11
- L'Officiel du jeu Scrabble
- OD (disambiguation)
- Occupy Dame Street
- Odds
- Odesa International Airport
- Office of Digital Strategy
- Old Dock Sill
- One Day School
- Online dating service
- OpenDNSSEC
- OpenDocument
- Operating Deflection Shape
- Operation Defensive Shield
- Operation Desert Storm
- Operational data store
- Optical data storage
- Ordbog over det danske Sprog
- Osmotic demyelination syndrome
- Overdose
- Oxide dispersion strengthened
- Ozone-depleting substance
- Pandorum