O'Beirne
O'Beirne may refer to:
- Frank O'Beirne, farmer, businessman, Irish Republican activist and Fianna Fáil politician in County Sligo
- Joseph O'Beirne, Irish professional footballer who played as an inside forward
- Kate O'Beirne, Washington editor of National Review
- Paul O'Beirne, American saxophonist notable as a member of Rocket from the Crypt
- Thomas O'Beirne, Anglican bishop, Bishop of Ossory from 1795 to 1798 when he was translated to Meath