Nucleobindin 1

Nucleobindin-1, also known as calnuc, is a protein that in humans is encoded by the NUCB1 gene.

Structure

The human calnuc protein contains 461 amino acids and has a pI of 4.9.
The protein contains the following regions and domains:

Signal peptide
Leucine-zipper The leucine-zipper of calnuc may be responsible for its dimerization.
aa 347-389 – Nuclear localization signal
2 zinc binding sites with high affinity
carboxypeptidase-like motifs : HFREXnH and HFTEXnH
2 EF-hands
Potential anchor region– 15-aa hydrophobic region at its COOH terminus that may be sufficient for membrane anchoring