| Loss | 2007 | US Open | Hard | 
Year–end championshipsDjokovic has won a record seven year-end championships. He also holds a record streak of four titles from 2012 to 2015.
Year–end championship finals: 9 (7 titles, 2 runner-ups)| Result | Year | Tournament | Surface | Opponent | Score | | Win | 2008 | Tennis Masters Cup | Hard |  Djokovic has won a record 40 ATP 1000 titles and he is the only player to complete the Career Golden Masters by winning all ATP 1000 tournaments of the tennis calendar, a feat he achieved twice. He also holds the record for most ATP 1000 titles won in a season with six titles in 2015.
ATP Tour finalsSingles: 145 (101 titles, 44 runner-ups)signifies the nine tournaments where Djokovic won the title after saving at least one match point
| Result | W–L | Date | Tournament | Tier | Surface | Opponent | Score | | Win | 1–0 | [2006 Dutch Open – Singles|] | Dutch Open, Netherlands | ATP 250 | Clay | dts|Jul 2006
Doubles: 3 (1 title, 2 runner-ups)| Result | W–L | Date | Tournament | Tier | Surface | Partner | Opponents | Score | | Loss | 0–1 | [2007 Next Generation Adelaide International – Doubles|] | Adelaide International, Australia | ATP 250 | Hard | 
Singles: 6 (6 titles)| Result | W–L | Date | Tournament | Tier | Surface | Opponent | Score | | Win | 1–0 | | Budapest Challenger, Hungary | Challenger | Clay | dts|Nov 2004
Doubles: 1 (title)| Result | Date | Tournament | Tier | Surface | Partner | Opponents | Score | | Win | | F5 Čačak, Serbia and Montenegro | Futures | Clay | 
ATP rankingDjokovic has spent the most weeks as ATP world No. 1, a record total of 428. He had been ranked No. 1 in a record 13 different years and finished as year-end No. 1 a record eight times. Djokovic also holds the record for most points accumulated at the top of the rankings.
ATP world No. 1Span holding the No. 1 ranking
Weeks at No. 1 by decade2010s2020s
Wins over top-10 ranked playersDjokovic has the record of most wins over top-10 ranked players in the Open Era, a total 265 victories. He also holds a season-record of 31 victories over top-10 players which he set in 2015. In 2011, in a seven-tournament span, Djokovic had the most dominant record versus a world No. 1, defeating then No. 1, Rafael Nadal in the finals of five prestigious events; Indian Wells Open, Miami Open, Madrid Open, Italian Open, and Wimbledon before overtaking him as No. 1.
Winning streaksDjokovic has had ten 20+ match win streaks in his career: 43, 29, 28, 28, 23, 22, 22 and 20.
43–win streak 2010–11Djokovic's 43-match winning streak in 2010–11 is the fifth longest in the Open Era. It also covers 41 straight match wins since the start of 2011, which is the second longest winning streak to start a season after John McEnroe's 42 wins in 1984.
| No. | Match | Tournament | Tier | Surface | Date | Round | Opponent | Rank | Score | | / | 427 | ATP Tour Finals | ATP Finals | Hard | 21.11.2010 | SF | 
43–win streak in Australia 2019–24Djokovic's 43-match winning streak in Australia began at the Australian Open in 2019 and ended at the 2024 United Cup.
| No. | Tournament | Tier | Surface | Date | Round | Opponent | Rank | Score | | / | Australian Open | Grand Slam | Hard | 15.01.2018 | R16 |  Djokovic won 30-consecutive singles matches at majors which is the longest winning streak in the Open Era at Grand Slam tournaments. By doing so, he became the third man in tennis history to hold all four major titles at once, joining Don Budge six majors in 1937–38 and Rod Laver four majors in 1962 and four majors in 1969.
| No. | Tournament | Surface | Date | Round | Opponent | Rank | Score | | / | 2015 French Open | Clay | 24.05.2015 | F | 
Historic achievementsThe following is a list of some of Djokovic's most significant achievements.
- Most Big Titles won
- Most Grand Slam titles
- Most ATP Masters titles
- Most Year-end Championship titles
- Most weeks ranked as world No. 1
- Most weeks ranked in top 2
- Most weeks ranked in top 3
- Most weeks ranked in top 4
- Most different years ranked as No. 1
- Most ranking points as No. 1
- Most year-end No. 1 finishes
- Most victories over top-10 players
- Highest career prize earnings
- Winning head-to-head record against Big Three rivals
- Winner of all Grand Slam titles, all Masters titles, Year-end Championship and the Olympic Gold
- Winner of each of the four majors and the Year-end Championship at least three times
- Winner of all Masters titles at least twice
CoachesCurrent coaches in bold:
Career milestone wins- ''Note: Bold indicates that he went on to win the tournament.''
Milestone Grand Slam match wins| # | Date | Age | Player | Event | Surface | Rd | Score | | 1. | May 2005 | 18 years | 
Milestone clay court match wins| # | Date | Age | Player | Event | Surface | Rd | Score | | 1. | September 2004 | 17 years, 4 months | 
Milestone grass court match wins| # | Date | Age | Player | Event | Surface | Rd | Score | | 1. | June 2005 | 18 years, 1 month |  The tournaments won by Djokovic are in boldface.
- Djokovic has been seeded 1st in record 33 Grand Slam tournaments, with 10 of those being consecutive.
- He had been seeded 1st or 2nd for 26 consecutive grand slams.
- Prior 2022 Australian Open Djokovic lost his ability to compete when his visa to enter Australia was cancelled and he would be denied entry to the country due to not meeting exemption criteria to Australia's vaccination requirements.
| Year | Australian Open | French Open | Wimbledon | US Open | | 2003 | did not play | did not play | did not play | did not play | | 2004 | did not play | did not play | did not play | did not play | | 2005 | not seeded | not seeded | not seeded | not seeded | | 2006 | not seeded | not seeded | not seeded | 20th | | 2007 | 14th | 6th | 4th | 3rd | | 2008 | 3rd | 3rd | 3rd | 3rd | | 2009 | 3rd | 4th | 4th | 4th | | 2010 | 3rd | 3rd | 3rd | 3rd | | 2011 | 3rd | 2nd | 2nd | 1st | | 2012 | 1st | 1st | 1st | 2nd | | 2013 | 1st | 1st | 1st | 1st | | 2014 | 2nd | 2nd | 1st | 1st | | 2015 | 1st | 1st | 1st | 1st | | 2016 | 1st | 1st | 1st | 1st | | 2017 | 2nd | 2nd | 2nd | did not play | | 2018 | 14th | 20th | 12th | 6th | | 2019 | 1st | 1st | 1st | 1st | | 2020 | 2nd | 1st | tournament cancelled* | 1st | | 2021 | 1st | 1st | 1st | 1st | | 2022 | 1st | 1st | 1st | did not play** | | 2023 | 4th | 3rd | 2nd | 2nd | | 2024 | 1st | 1st | 2nd | 2nd | | 2025 | 7th | 6th | 6th | 7th | | 2026 | 4th | | | |
* ''** ''
National representationDavis CupParticipations: 62 (46–16)
Team competitions finals| Result | Date | Tournament | Surface | Partners | Opponent | Score | | Loss | [2008 Hopman Cup|] | Hopman Cup, Australia | Hard | 
Exhibition matchesDoubles| Result | Date | Tournament | Surface | Partner | Opponents | Score | | Win | Nov 2013 | Buenos Aires, Argentina | Hard | 
Mixed doubles| Result | Date | Tournament | Surface | Partner | Opponents | Score | | Loss | Dec 2024 | El Último Desafío, Buenos Aires, Argentina | Hard | 
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