North Main Street Historic District
- Central Park-North Main Street Historic District
- East Main Street Historic District (disambiguation)
- Laverne's North Main Street District
- Main Street Historic District (disambiguation)
- Monticello North Main Street Historic District
- National Register of Historic Places listings in Cobb County, Georgia
- National Register of Historic Places listings in Fond du Lac County, Wisconsin
- National Register of Historic Places listings in Forrest County, Mississippi
- National Register of Historic Places listings in Harper County, Oklahoma
- National Register of Historic Places listings in Henderson County, Kentucky
- National Register of Historic Places listings in Hopkins County, Kentucky
- National Register of Historic Places listings in Knox County, Ohio
- National Register of Historic Places listings in Macon County, Alabama
- National Register of Historic Places listings in Maury County, Tennessee
- National Register of Historic Places listings in Mercer County, Kentucky
- National Register of Historic Places listings in Owen County, Kentucky
- National Register of Historic Places listings in Pulaski County, Kentucky
- National Register of Historic Places listings in Rock County, Wisconsin
- National Register of Historic Places listings in Shelby County, Tennessee
- National Register of Historic Places listings in Winnebago County, Wisconsin
- North Main Avenue Historic District
- North Main Street (disambiguation)
- North Main Street Commercial Historic District (Statesboro, Georgia)
- North Main Street Historic District (Bolivar, Tennessee)
- North Main Street Historic District (Canandaigua, New York)
- North Main Street Historic District (East Hampton, New York)
- North Main Street Historic District (Graham, North Carolina)
- North Main Street Historic District (Greenville, Kentucky)
- North Main Street Historic District (Hannibal, Missouri)
- North Main Street Historic District (Mocksville, North Carolina)
- North Main Street Historic District (Moravia, New York)
- North Main Street Historic District (Poplar Bluff, Missouri)
- North Main Street Historic District (Salisbury, North Carolina)
- North Main Street Historic District (Southampton, New York)
- North Main-Bank Streets Historic District
- North Main-North Detroit Street Historic District
- South Main Street Historic District (disambiguation)
- West Main Street Historic District (disambiguation)