Naked cuticle 2
Naked cuticle 2 is a human gene that encodes the protein Nkd2, one of the Naked cuticle (Nkd) family of proteins that regulate the Wnt [signaling pathway]. Both Nkd1 and Nkd2 proteins can bind to Dishevelled proteins, but only Nkd2 can bind to the Epidermal [growth factor|EGF]-ligand family member TGF alpha and regulate its polarized secretion in cultured epithelial cells.