She started stage acting and she first acted in films in 1960s. She appeared in Urdu, Punjabi and Pashto films. She also sangsongs in films and she then starred in some of Abid Ali's dramas. She also appeared in telefilms and dramas. She appeared in PTV drama Samunder and Boota from Toba Tek Singh. For her contributions towards the television industry, she was honored by the Government of Pakistan with the Pride of Performance in 2018.
Personal life
Nighat was married to actor Abid Butt until his death in 2013. They had four biological children: three daughters, and one son named Nomi Butt. She also adopted and raised her deceased brother's two children.