NicO transporters
The Nickel/Cobalt Transporter Family is a member of the Lysine Exporter (LysE) Superfamily.
Homology
Homologues of the NicO family have differing predicted topologies: 6, 7 and 8 TMSs. One such homologue, RcnA of E. coli has 6 putative transmembrane segments in a 3 + 3 arrangement with a large hydrophilic loop between putativeTMSs 3 and 4. Several homologues of RcnA have 7 putative TMSs. Still another homologue, UreH of Methanocaldococcus janaschii has 6 putative TMSs in a more characteristic 3 + 3 TMS arrangement. The NicO family within the LysE superfamily may have a common origin with the TOG superfamily, having lost TMSs 1 and 4 in the 8 TMS TOG superfamily topology.Function
This protein is believed to catalyze Co2+ and Ni2+ efflux.The overall reaction catalyzed by proteins of the NicO family is probably:
→ .