Neurotensin receptor 2Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.FunctionThe protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds Neurotensin as well as several other ligands already described for Neurotensin receptor 1. NT function is known to be a of dopamine and has and properties in the brain and some peripheral organ function as well. NTS2 is found mostly in the brain through Northern-blot analysis.Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.