Naxos syndrome
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Naxos syndrome or Naxos disease is a cutaneous condition characterized by a palmoplantar keratoderma. The prevalence of the syndrome is up to 1 in every 1000 people in the Greek islands.
It has been associated with mutations in the genes encoding the proteins desmoplakin, plakoglobin, desmocollin-2, and SRC-interacting protein. Naxos disease has the same cutaneous phenotype as the Carvajal syndrome.
Symptoms
Between 80 and 99% of those with Naxos disease will display some of the following symptoms:- Disease of the heart muscle
- Thickening of palms and soles
- Sudden increased heart rate
- Dizzy spells
- Kinked hair