Naked cuticle 2
Naked cuticle 2 is a human gene that encodes the protein Nkd2, one of the Naked [cuticle (Nkd)] family of proteins that regulate the Wnt signaling pathway. Both Nkd1 and Nkd2 proteins can bind to Dishevelled proteins, but only Nkd2 can bind to the EGF-ligand family member TGF alpha and regulate its polarized secretion in cultured epithelial cells.