Her parents were George Holmes and Sarah Akweley Kotey, she lived in Nigeria with her Uncle Charles Holmes at a Tender age where she attended school. She moved back to Ghana because her mum was sick and she continue her education at Adabraka Methodist School where she completed her standard seventh education.
In 1963 she was enstooled as the Queen Mother of the Ga State at age 29. She took the stool name Naa Dedei Omaedru III, a name she took from her grand-mother Naa Dedei Omaedru II.