Nucleoporin 85
Nucleoporin 85 is a protein that in humans is encoded by the NUP85 gene.Function
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.Model organisms
s have been used in the study of NUP85 function. A conditional knockout mouse line called Nup85tm1aWtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
