NSD3

Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the NSD3 gene.
This gene is related to the Wolf–Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described.
The NSD3 gene is amplified in several cancers, including lung cancer and head and neck cancer, and may play a role in carcinogenesis.