NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.FunctionThis gene is a member of the nuclear factor of activated T cells family. The product of this gene is a DNA-binding protein with a REL-homology region and an NFAT-homology region. This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Clinical significanceTranslocation forming an in frame fusions product between Ewing sarcoma [breakpoint region 1|EWSR1 gene] and the NFATc2 gene has been described in bone tumor with a Ewing sarcoma-like clinical appearance. The translocation breakpoint led to the loss of the controlling elements of the NFATc2 protein and the fusion of the N terminal region of the EWSR1 gene conferred constant activation of the protein.InteractionsNFATC2 has been shown to interact with MEF2D, EP300, IRF4 and Protein kinase Mζ. Prostaglandin F2alpha stimulates a NFCT2 pathway stimulating growth of skeletal muscle cells.