MSC
- Air Cairo
- Falcon Field (Arizona)
- List of mine warfare vessels of the United States Navy
- MIDI Show Control
- MSC (gene)
- MSC Air Cargo
- MSC Cruises
- MSC Industrial Direct
- MSC Malaysia
- MSC Software
- Mabuhay Satellite Corporation
- Mail services center
- Mammary secretory carcinoma
- Managed service company
- Management saved console
- Manchester Ship Canal
- Manned Spacecraft Center
- Manpower Services Commission
- Marianites of Holy Cross
- Marinduque State University
- Marine Stewardship Council
- Maritime Safety Committee
- Maryland Science Center
- Master of Science
- Mastère en sciences
- Mathematics Subject Classification
- Matthews Southern Comfort
- Mechanosensitive channels
- Medical Service Corps
- Mediterranean Shipping Company
- Meritorious Service Cross
- Mesa State College
- Mesenchymal stem cell
- Message Sequence Chart
- Messinian salinity crisis
- Meteorological Service of Canada
- Metric Systems Corporation
- Metro Suburban Conference
- Metropolitan Special Constabulary
- Michael Schumacher
- Microelectronics Support Centre
- Microsoft Visual C++
- Mid-South Conference
- Miles of Standard Cable
- Military Sealift Command
- Military Staff Committee
- Missionaries of the Sacred Heart
- Mobile Switching Center
- Mohammedan Sporting Club (Chittagong)
- Mohammedan Sporting Club (Dhaka)
- Mohammedan Sporting Club (Kolkata)
- Mombasa Sports Club
- Motorcycle Stability Control
- Mount Saint Charles Academy
- Mouse Systems Corporation
- Movimiento Scout Católico
- Munich Security Conference
- Munsang College
- USB mass storage device class