bequeathed his fortune to establish "a hospital for the reception and relief of sick and diseased persons," but further funds had to be raised before building and running Roosevelt Hospital. The hospital's first building opened and it began operations on November 2, 1871, seven years after its establishment. A plaque to its namesake and benefactor reads: "To the memory of James Henry Roosevelt, a true son of New York, the generous founder of this hospital, a man upright in his aims, simple in his life, and sublime in his benefaction."
Buildings were added over time to meet the demands for growth and improved facilities. Additions included the Private-Patient Pavilion, the William J. Syms Operating Theatre, the Accident Building and Ward for Sick Children, a Nurses' Residence, a taller Ward building, the James I. Russell Memorial Surgical Building, the Tower Memorial Building, the School of Nursing, the Garrard Winston Memorial Building, The Arthur J. Antenucci Institute of Medical Research and a new main hospital facility facing Tenth Avenue – a 13-story Skidmore, Owings & Merrill-designed facility was that started construction in 1990 and opened in 1992. Much of the original hospital, including the emergency room, was torn down to make way for two 49-story residential buildings at One Columbus Place. The oldest remaining component of the hospital is the William J. Syms Operating Theater, named after its benefactor, a gun merchant. Syms left $350,00 in his will to fund the operating theater “as an enduring monument to himself and at the same time do a great service for suffering humanity.” The theater was designed by architect William Wheeler Smith and recognized among the first equipped for aseptic surgery. After hosting its last surgery in 1941, it alternately functioned as a blood bank, emergency room and morgue. The free-standing building is now a designated New York City landmark building.
and Roosevelt Hospital merged in 1978, becoming St. Luke's–Roosevelt Hospital Center. The hospitals became part of the Mount Sinai Health System in 2013. On November 17, 2015, St. Luke's–Roosevelt rebranded for the first time in 146 years and christened Mount Sinai West – against the objection of the Roosevelt family. On February 7, 2020, Mount Sinai St. Luke's was renamed Mount Sinai Morningside and was separated from Mount Sinai West.
Mount Sinai West sponsors 30 accredited residency training programs. The Department of Medicine trains 158 residents and an additional 39 fellows, one of the largest programs in New York State and in the top 10 largest programs nationally. Each program enjoys full accreditation from the Accreditation Council for Graduate Medical Education, and the institution is accredited for the maximum 5-year cycle. The Internal Medicine Training Program utilizes strategies that encourages residents learn from every patient. Innovations include a drip system for distributing admissions and no overnight call anywhere in the training program. The department limits the number of patients that can be carried by an intern to no more than 10. 83% of the programs in New York, New Jersey, and all of New England still allow interns to carry 12 patients. The program also has its own "Simulation Lab" for training residents. The residency program in Anatomic and Clinical Pathology is the only one to utilize Mount Sinai Beth Israel in addition to Mount Sinai Morningside and Mount Sinai West. Residents have exposure to over 70,000 cases, which cover a wide variety of disease processes, and range from routine to complex and unusual disease entities.