Mistrustin' Blues"Mistrustin' Blues" is a 1950 song written by Johnny Otis.OverviewIt was sung by Little Esther and Mel Walker, accompanied by The Johnny Otis Orchestra, and released on the Savoy label. The record was the second collaboration between Johnny Otis and Little Esther. "Mistrustin Blues" was their second number one record on the R&B chart, which it topped for four weeks. It was ranked No. 10 on Billboard magazine's year-end list of R&B records for 1950 based on sales.