Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution
Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution is a scholarly work by Claus O. Wilke and D. Allan Drummond, published in 2008 in ''Cell''. The main subjects of the publication include purifying selection, biology, RNA sequencing, RNA splicing, coding region, genetics, codon usage bias, protein evolution, computational biology, Nonsynonymous substitution, ribosome, molecular evolution, sequence space, biological sequence, gene, Synonymous substitution, evolutionary biology, and protein folding. The authors propose, and demonstrate using a molecular-level evolutionary simulation, that selection against toxicity of misfolded proteins generated by ribosome errors suffices to create all of the observed covariation.