Missouri Route 53
Route 53 is a highway in southeastern Missouri. Its southern terminus is at Route [25 (Missouri)|Route 25] in Holcomb. Its northern terminus is at Business U.S. [Route 67 Business (Poplar Bluff, Missouri)|U.S. Route 67 Business] in Poplar Bluff.
Route 53 is one of the original state highways and has remained essentially unchanged since 1922.