N-Methylpiperazine


N-Methylpiperazine is a heterocyclic organic compound.

Uses

N-Methylpiperazine is a common building [block (chemistry)|building block] used in organic synthesis. For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine, meclizine, and sildenafil.
The lithium salt, lithium N-methylpiperazide, is used as a reagent in organic synthesis for protection of aryl aldehydes.

Synthesis

Industrially, N-methylpiperazine is produced by reacting diethanolamine and methylamine at 250 bar and 200 °C.