Methyl-TMA-2


Methyl-TMA-2, or N-methyl-TMA-2, also known as N-methyl-2,4,5-trimethoxyamphetamine, is a drug of the phenethylamine, amphetamine, and DOx families. It is the N-methyl derivative of 2,4,5-trimethoxyamphetamine as well as the α,N-dimethyl derivative of 2C-O.

Use and effects

N-Methylation of psychedelic phenethylamines has invariably greatly reduced or eliminated their hallucinogenic activity. Examples of this include related compounds like Beatrice and methyl-DOB, which at assessed doses appear to be inactive as psychedelics in humans. In accordance with the preceding findings, per Alexander Shulgin in his book PiHKAL, methyl-TMA-2 was inactive at doses of up to 120mg. For comparison, the active dose range of TMA-2 is 20 to 40mg.

History

Methyl-TMA-2 was first described in the scientific literature by at least 1984. It was subsequently described further by Shulgin in PiHKAL in 1991.

Society and culture

Legal status

Canada

Methyl-TMA-2 is a controlled substance in Canada under phenethylamine blanket-ban language.