Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development
Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development is a scholarly work by Anne M Moon, published in 2014 in ''Developmental Biology''. The main subjects of the publication include copy-number variation, -, biology, cell biology, computational biology, hippo signaling, field, and development of the heart. The authors found that heart development appeared normal after endodermal deletion of Nkx2.5 whereas mesodermal deletion engendered cardiac defects almost identical to those observed on Nkx2.5 null embryos (Nkx2.5(-/-)).