Melicope polybotrya is a shrub or tree that typically grows to a height of. The leaves are arranged in opposite pairs and trifoliate on a petiole long. The leaflets are more or less round to broadly egg-shaped with the narrower end towards the base, long and wide on a petiolule long. The flowers are arranged in panicles long and wide with several to many flowers. The plants are dioecious, with male and female flowers on separate plants. The sepals are long and the petals are green, long. Flowering occurs in summer and the fruit consists of four follicles long and fused at the base, containing spherical black seeds.