Medoc, MissouriMedoc is an unincorporated community in Jasper County, in the U.S. state of Missouri.HistoryMedoc was platted in 1856, and named after the Medoc Indians. A post office called Medoc was established in 1854, and remained in operation until 1927.Notable peopleFred Grayson Sayre, Engraver, illustrator and painter.