Mebfap


Mebfap, also known as 1--2-aminopropane or 5-methoxy-3-benzofuran as well as 1-oxa-5-MeO-AMT, is a serotonin receptor modulator of the benzofuran family related to the psychedelic tryptamine 5-MeO-AMT. It is the analogue and bioisostere of 5-MeO-AMT in which the nitrogen atom of the indole ring has been replaced with an oxygen atom, resulting in the drug being a benzofuran rather than tryptamine derivative. Mebfap is a ligand of serotonin receptors similarly to 5-MeO-AMT, but shows about 6-fold lower affinity than 5-MeO-AMT. It was first described in the scientific literature by David E. Nichols and colleagues by 1992.