McN 5707
Mcn 5707 is a SNDRI agent designated for the treatment of depression. It was developed by Bruce Maryanoff of McNeil in the 1980s.
Ki digits
These are the Ki digits:| Compound 24b | DA | NE | SER |
| racemic | 35.9 | 1.9 | 8.5 |
| 17.5 | 1.1 | 5.5 | |
| 775 | 261 | 537 |
As can be seen most of the Ki activity resides in a single optical antipode. Hence, there is a good eudysmic ratio
SAR
For related agents, see: JNJ-7925476, McN-4612, McN-5292, McN-5558, McN5652 & McN-5908.Other examples of ortho-chloro-phenyl rings include:
- Ketamine
- Clofedanol
- Clortermine
- Tulobuterol
- Disobutamide
- Bidisomide