List of mayors of Harrisburg, Pennsylvania
This list of mayors of Harrisburg, Pennsylvania is sorted chronologically, by default. The current mayor, since January 2022, is Democrat Wanda Williams.
| Mayor | Term | Political party | Notes |
| William H. Kepner | – Mar 27, 1863 | Democratic | |
| Augustus L. Roumfort | – Mar 23, 1866 | Democratic | |
| Oliver Edwards | – Jan 11, 1869 | Democratic | |
| William W. Hays | – Mar, 1870 | Republican | Died in office. |
| George B. Cole | – Jan 9, 1871 | Republican | |
| William K. Verbeke | – Jan 13, 1873 | Democratic | |
| Jacob D. Boas | – Jan 11, 1875 | Republican | |
| John D. Patterson | – Jan 8, 1881 | Republican | Resigned. |
| John Crull Herman | – Apr 2, 1883 | Republican | |
| Simon Cameron Wilson | – 1886 | Republican | Died in office. |
| Samuel W. Fleming Sr. | 1886–1887 | Republican | |
| John A. Fritchey | 1887–1893 | Democratic | |
| Maurice C. Eby | 1893–1896 | Republican | |
| John D. Patterson | 1896–1899 | Republican | |
| John A. Fritchey | 1899–1902 | Democratic | |
| Vance C. McCormick | 1902–1905 | Democratic | |
| Edward Z. Gross | 1905–1908 | Republican | |
| Ezra S. Meals, M.D. | 1908–1912 | Republican | |
| John K. Royal | 1912–1916 | Democratic | |
| Ezra S. Meals, M.D. | 1916 – April 18, 1917 | Republican | Died in office. |
| William L. Gorgas | – May 15, 1917 | Democratic | Named acting mayor following Dr. Meals' death. |
| Charles A. Miller | – July 12, 1917 | Republican | Died in office. |
| William L. Gorgas | – Sep 24, 1917 | Democratic | Named acting mayor following Miller's death. |
| J. William Bowman | – Nov 27, 1917 | Republican | Appointed for six weeks' time and retired from office. |
| Daniel L. Keister | – Jan 5, 1920 | Republican | |
| George A. Hoverter | – Jan 6, 1936 | Republican | |
| John A. F. Hall | – Jan 1, 1940 | Republican | |
| Howard E. Milliken, M.D. | – Jan 5, 1948 | Republican | |
| Claude R. Robins | – Jan 2, 1956 | Republican | |
| Nolan F. Ziegler | – Mar 7, 1963 | Republican | Died in office. |
| Daniel J. Barry | – Jan 6, 1964 | Republican | |
| William K. McBride | – Jan 1, 1968 | Republican | |
| Albert H. Straub | – Jan 5, 1970 | Republican | |
| Harold A. Swenson | – Jan 1, 1978 | Democratic | First "strong" mayor after switch to strong mayor variation of Mayor–council government. |
| Paul E. "Tim" Doutrich, Jr. | – Jan 5, 1982 | Republican | |
| Stephen R. Reed | – Jan 4, 2010 | Democratic | Defeated for renomination in 2009. |
| Linda D. Thompson | – Jan 6, 2014 | Democratic | Defeated for renomination in 2013; first female and first black mayor. |
| Eric R. Papenfuse | – Jan 3, 2022 | Democratic | Reelected November 2017; defeated for renomination and lost write-in campaign in November 2021. |
| Wanda R. D. Williams | – present | Democratic |