Mark DeSantis

• Mark DeSantis (businessman), American entrepreneur and political pundit
• Mark DeSantis (ice hockey), Canadian ice hockey defenceman and coach
• Marko DeSantis, American lead guitarist for rock band Sugarcult
• Mark DeSantis, professor of finance, see Gunduz Caginalp
• Mark DeSantis, outside linebacker with the 1976, 1977, and 1978 Michigan Wolverines football teams