Mario Sergio
Mario Sergio may refer to:
- Mário Sérgio (actor, born 1929), Brazilian actor
- Mario Sergio (politician), Canadian politician
- Mário Sérgio (footballer, born 1950), Brazilian football manager and former midfielder
- Mário Sérgio (footballer, born 1977), Brazilian football midfielder
- Mário Sérgio (footballer, born 1981), Portuguese football right-back
- , Colombian footballer
- Mario Sérgio Lotufo, Brazilian water polo player
- Mário Sérgio (footballer, born 1992), Brazilian football defender
- Mário Sérgio (footballer, born 1995), Brazilian football forward