Mario Méndez

• Mario Méndez (Mexican footballer), Mexican football player
• Mario Méndez (Panamanian footballer), Panamanian football defender and manager
• Mario Méndez (Uruguayan footballer), Uruguayan footballer
• Mario Mendez (politician), American politician in the Rhode Island House of Representatives
• Mario Méndez Montenegro, assassinated first elected mayor of Guatemala City
• Mario Rafael Méndez Martínez, Mexican politician